Synthesis and antibacterial activity of ciprofloxacin derivatives / 药学学报
Acta Pharmaceutica Sinica
;
(12): 132-135, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-241361
ABSTRACT
<p><b>AIM</b>To study the synthesis and antibacterial activity of ciprofloxacin derivatives.</p><p><b>METHODS</b>Ciprofloxacin derivatives were synthesized primarily from 2-methyl-5-nitroimidazol and ciprofloxacin through nucleophilic substitution. The antibacterial activity of the synthesized compounds were tested.</p><p><b>RESULTS</b>Nine new compounds were synthesized. The structure of the title compounds were confirmed by 1H NMR, MS and element analysis.</p><p><b>CONCLUSION</b>Compounds II, IVC and IVD showed appreciable antibacterial activity, and were worth further studying.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Molecular Structure
/
Ciprofloxacin
/
Chemistry
/
Escherichia coli
/
Anti-Infective Agents
/
Nitroimidazoles
Limits:
Animals
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2005
Type:
Article
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