Pharmacokinetics of beta-asarone in rats / 药学学报

ABSTRACT

<p><b>AIM</b>To study the pharmacokinetics of beta-asarone in rats.</p><p><b>METHODS</b>The concentration of beta-asarone in serum and organs were measured by HPLC after i.g. administration, the pharmacokinetics was analyzed with DAS software regarding the organs as independent system.</p><p><b>RESULTS</b>The pharmacokinetics of beta-asarone can be described as first order process of one-compartment model. In the serum, T(1/2), Tpeak and Cmax were 54 min, 12 min and 3.19 mg x L(-1), respectively. The procedure in the organs was similar to that in serum.</p><p><b>CONCLUSION</b>The absorption, distribution and elimination of beta-asarone are very rapid, and it is easy to pass through blood brain barrier. Brain is an important organ of distributing of beta-asarone.</p>