Association between MAOA-u VNTR polymorphism and its interaction with stressful life events and major depressive disorder in adolescents / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 563-568, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-241472
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether the genetic polymorphism, upstream variable number of tandem repeats (uVNTR), in the monoamine oxidase A (MAOA) gene, is associated with major depressive disorder (MDD) in adolescents and to test whether there is gene-environment interaction between MAOA-uVNTR polymorphism and stressful life events (SLEs).</p><p><b>METHODS</b>A total of 394 Chinese Han subjects, including 187 adolescent patients with MDD and 207 normal students as a control group, were included in the study. Genotyping was performed by SNaP-shot assay. SLEs in the previous 12 months were evaluated. The groups were compared in terms of the frequency distributions of MAOA-uVNTR genotypes and alleles using statistical software. The binary logistic regression model of gene-environment interaction was established to analyze the association of the gene-environment interaction between MAOA-u VNTR genotypes and SLEs with adolescent MDD.</p><p><b>RESULTS</b>The distribution profiles of MAOA-u VNTR genotypes and alleles were not related to the onset of MDD, severity of depression, comorbid anxiety and suicidal ideation/behavior/attempt in adolescents. The gene-environment interaction between MAOA-u VNTR genotypes and SLEs was not associated with MDD in male or female adolescents.</p><p><b>CONCLUSIONS</b>It is not proven that MAOA-u VNTR polymorphism is associated with adolescent MDD. There is also no gene-environment interaction between MAOA-u VNTR polymorphism and SLEs that is associated with adolescent MDD.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Logistic Models
/
Minisatellite Repeats
/
Depressive Disorder, Major
/
Gene-Environment Interaction
/
Genetics
/
Genotype
/
Life Change Events
/
Monoamine Oxidase
Type of study:
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Type:
Article
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