Research progress on periventricular white matter damage pathogenesis in preterm infants / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 396-following 400, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-241509
ABSTRACT
Periventricular white matter damage is one of the characteristics of brain damage in preterm infants, and it is the most important type of encephalopathy. The pathological changes including the white matter of coagulation necrosis, oligodendrocyte damage, myelin damage, axonal injury and reactive gliosis and microglia infiltration in necrotic areas. All of these lesions are closely related to the nervous system sequelae in later-neonatal period. The pathogenesis of periventricular leukomalacia in premature infants are mainly cause by its immature brain vascular, and precursor oligodendrocytes of the attack of hypoxia, ischemia, infection, oxygen free radicals, inflammatory cytokines, increasing glutamate, and other high-risk factors. In this paper, an overview of progress in the study of the pathogenesis of periventricular white matter damage in premature infants through literature review to provide a theoretical support for clinical prevention, diagnosis and treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Leukomalacia, Periventricular
/
Infant, Premature
/
Cerebrovascular Circulation
/
Risk Factors
/
Cytokines
/
Classification
/
Apoptosis
/
Excitatory Amino Acids
/
Toxicity
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Type:
Article
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