Expression of P38 MAPK and MMP-2 mRNA in neonatal rats with hyperoxia-induced lung injury / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 383-386, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-241513
ABSTRACT
<p><b>OBJECTIVE</b>To observe P38 mitogen-activated protein kinase (P38 MAPK) and matrix metalloproteinase-2 (MMP-2) mRNA expression level changes in neonatal rats with hyperoxia-induced lung injury,and to investigate the influence of P38 MAPK activation on MMP-2 mRNA expression.</p><p><b>METHODS</b>Thirty-six Sprague-Dawley (SD) rats were randomly divided into three groups air control, hyperoxia and SB203580-treated hyperoxia (n=12). The rats were sacrificed on the 3rd and 7th days and the lungs were removed. Hematoxylin-eosine staining was used to observe the pathological changes in lung tissues.</p><p><b>RESULTS</b>Compared with the air and SB203580-treated groups, levels of P38 MAPK and MMP-2 mRNA significantly increased in the hyperoxia group (P<0.01).</p><p><b>CONCLUSIONS</b>Expression of P38 MAPK increases in neonatal rats with hyperoxia-induced acute lung injury and this may play a role in control of the expression of MMP-2 mRNA.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Rats, Sprague-Dawley
/
Hyperoxia
/
Tissue Inhibitor of Metalloproteinases
/
Matrix Metalloproteinase 2
/
P38 Mitogen-Activated Protein Kinases
/
Lung Injury
/
Genetics
/
Lung
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS