Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type II as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 483-490, 2011.
Article
in English
| WPRIM
| ID: wpr-241570
ABSTRACT
<p><b>BACKGROUND</b>The expression of genes encoding a number of pathogenetic pathways involved in colorectal cancer could potentially act as prognostic markers. Large prospective studies are required to establish their relevance to disease prognosis.</p><p><b>METHODS</b>We investigated the relevance of 19 markers in 790 patients enrolled in a large randomised trial of 5-fluorouracil using immunohistochemistry and chromogenic in situ hybridisation. The relationship between overall 10-year survival and marker status was assessed.</p><p><b>RESULTS</b>Minichromosome maintenance complex component 2 (MCM2) and cyclin A were significantly associated with overall survival. Elevated MCM2 expression was associated with a better prognosis (HR = 0.63, 95%CI 0.46 - 0.86). Cyclin A expression above the median predicted an improved patient prognosis (HR = 0.71, 95%CI 0.53 - 0.95). For mismatch repair deficiency and transforming growth factor β receptor type II (TGFBRII) overexpression there was a borderline association with a poorer prognosis (HR = 0.69, 95%CI 0.46 - 1.04 and HR = 2.11, 95%CI 1.02 - 4.40, respectively). No apparent associations were found for other markers.</p><p><b>CONCLUSION</b>This study identified cell proliferation and cyclin A expression as prognostic indicators of patient outcome in colorectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Prognosis
/
Colorectal Neoplasms
/
Prospective Studies
/
Protein Serine-Threonine Kinases
/
In Situ Hybridization
/
Receptors, Transforming Growth Factor beta
/
Ki-67 Antigen
/
Cyclin A
/
Tissue Array Analysis
Type of study:
Controlled clinical trial
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2011
Type:
Article
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