Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2327-2331, 2014.
Article
in English
| WPRIM
| ID: wpr-241673
ABSTRACT
<p><b>BACKGROUND</b>Waldenström macroglobulinemia (WM) is an uncommon lymphoid malignancy. The characteristics and prognosis of WM have never been systematically studied in the East.</p><p><b>METHODS</b>We analyzed the clinical characteristics and the prognostic factors of 90 Chinese WM patients, and compared them with the Western reports.</p><p><b>RESULTS</b>The median age was 62 years old with a male-to-female ratio of 3.74. The most common symptoms at diagnosis were fatigue (77.8%) and bleeding (20%), while only 6 patients (6.7%) were asymptomatic. In the univariate analysis, age >62 years, thrombocytopenia, leucopenia, cytopenias ≥ 2, and high risk on the international prognostic scoring system for WM were the adverse risk factors, but only age >62 years and ≥ 2 cytopenias were the independent prognostic factors in the multivariate analysis. Using age <62 years and ≥ 2 cytopenias, three significantly different prognostic groups could been distinguished, with 5-year overall survival of 71.6%, 48.6%, and 17.0% (P < 0.001).</p><p><b>CONCLUSION</b>Distinct characteristics exist in WM in China compared to the West and we describe a new simple prognostic model for newly diagnosed WM patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Risk Factors
/
Mortality
/
Waldenstrom Macroglobulinemia
/
Diagnosis
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2014
Type:
Article
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