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Value of cytopathology in endobronchial ultrasound-guided transbronchial needle aspiration / 中华病理学杂志
Chinese Journal of Pathology ; (12): 44-47, 2012.
Article in Chinese | WPRIM | ID: wpr-242000
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the role of cytopathology in endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for lung tumor diagnosis and staging.</p><p><b>METHODS</b>Two-hundred consecutive cases of lung tumor with EBUS-TBNA performed during the period from April, 2009 to September, 2010 in Shanghai Cancer Hospital were retrospectively reviewed. The cytologic diagnoses were categorized as non-diagnostic, negative, suspicious and malignant. When available, cell block preparation and immunohistochemistry were performed. On the 22 positive cases diagnosed by on-site evaluation, epidermal growth factor receptor (EGFR) mutation study was carried out.</p><p><b>RESULTS</b>In the 200 cases of cytology specimens, 122 cases (69.3%) were diagnosed as malignant, 42 cases (23.9%) as benign and 12 cases (6.8%) as suspicious for malignancy. The non-diagnostic rate was 12.0% (24/200). Amongst the 200 cases studied, 140 cases (70.0%) had histologic correlation available (via core biopsy, mediastinoscopic biopsy or surgical excision). The sensitivity and specificity of EBUS-TBNA cytologic diagnoses were 94.4% and 100%, when using histopathologic findings and clinical follow-up data as gold standard. The cell block preparation and immunohistochemistry were useful in subtyping and diagnosis of extrathoracic malignancy. EGFR mutations were detected in 8 cytology samples (36.4%).</p><p><b>CONCLUSIONS</b>EBUS-TBNA is a sensitive and specific tool for diagnosis and staging of lung cancer. The cytology samples can be used for further ancillary investigations including cell block preparation, immunohistochemistry and molecular studies.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bronchi / Carcinoma, Squamous Cell / Adenocarcinoma / Exons / Retrospective Studies / Follow-Up Studies / Sensitivity and Specificity / Carcinoma, Small Cell / Endoscopic Ultrasound-Guided Fine Needle Aspiration Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Pathology Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bronchi / Carcinoma, Squamous Cell / Adenocarcinoma / Exons / Retrospective Studies / Follow-Up Studies / Sensitivity and Specificity / Carcinoma, Small Cell / Endoscopic Ultrasound-Guided Fine Needle Aspiration Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Pathology Year: 2012 Type: Article