Clinical study of DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 901-904, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-242030
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy of liposomal doxorubicin together with etoposide and high dose methylprednisolone (DEP) as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis (HLH).</p><p><b>METHODS</b>Total 41 patients with refractory HLH were enrolled in this study. The efficacy of treatment with DEP regimen after 2 and 4 weeks were evaluated according to the United States Midwest Cooperative HLH Group.</p><p><b>RESULTS</b>Of 41 refractory HLH patients, 28 were males and 13 females. The median age was 31(18-62) years old. The overall response rate (ORR) was 78.1%(32/41), including 12 patients (29.3%) achieved complete remission (CR) and 20 (48.8%) achieved partial remission (PR). The underlying disease of HLH were identified in 33 patients, including 1 case of primary HLH (CR), 20 cases of lymphoma associated HLH and 12 cases of EBV associated HLH. There were still 8 cases with unknown underlying disease. The 9 patients who had no response to DEP died within 2 to 4 weeks after salvage therapy. Twenty of the 32 patients who achieved PR or CR survived to undergo subsequent chemotherapy, allogenic hematopoietic stem cell transplantation (allo-HSCT) or splenectomy.</p><p><b>CONCLUSION</b>The single-arm study suggested that DEP regimen appeared to be an effective salvage protocol for adult patients with refractory HLH.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Remission Induction
/
Prednisone
/
Antineoplastic Combined Chemotherapy Protocols
/
Cisplatin
/
Salvage Therapy
/
Hematopoietic Stem Cell Transplantation
/
Therapeutic Uses
/
Drug Therapy
/
Lymphohistiocytosis, Hemophagocytic
/
Etoposide
Type of study:
Practice guideline
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Type:
Article
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