Chronic lymphocytic leukemia with central nervous system invasion: one case report and literature review / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 592-595, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-242109
ABSTRACT
<p><b>OBJECTIVE</b>To investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.</p><p><b>METHODS</b>The cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.</p><p><b>RESULTS</b>A clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.</p><p><b>CONCLUSION</b>CNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Central Nervous System
/
Leukemic Infiltration
Type of study:
Prognostic study
/
Screening study
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2014
Type:
Article
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