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Clinical investigation of reduced-dose voriconazole on primary prevention in invasive fungal disease after allogeneic hematopoietic stem cell transplantation / 中华血液学杂志
Chinese Journal of Hematology ; (12): 577-580, 2014.
Article in Chinese | WPRIM | ID: wpr-242112
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy and tolerability of intravenous voriconazole on primary prevention in invasive fungal disease (IFD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).</p><p><b>METHODS</b>At the time of conditioning regimen, patients without IFD was intravenously administered with voriconazole at a dose of 100 mg two times per day until neutrophils greater than 0.5×10⁹/L. Patients treated with oral fluconazole, 200 mg per day, were control group. The incidence and risk factors of IFD and side effects of medicines were evaluated.</p><p><b>RESULTS</b>Of the total 227 patients, 33 (14.54%) had IFD within 3 months after allo-HSCT. There was significant difference on overall survival between patients with or without IFD by Kaplan-Meier survival curve (P=0.029). Of the 83 cases with intravenous voriconazole, 7 cases occurred IFD (8.43%). In contrast, the incidence of IFD in control group was 18.06% (26 out of 144). There was remarkable difference between the two groups (P=0.048). But there was no significant difference on risk factors of IFD between the two groups. In addition, the incidence of liver function abnormalities between the two groups was no difference. The ratio of auditory hallucination and visual impairment induced by voriconazole was not high.</p><p><b>CONCLUSION</b>Intravenous voriconazole on primary prevention for IFD after allo-HSCT is much better than oral fluconazole with well tolerability and satisfactory efficacy.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Postoperative Complications / Fluconazole / Follow-Up Studies / Treatment Outcome / Hematopoietic Stem Cell Transplantation / Therapeutic Uses / Administration, Intravenous / Voriconazole / Mycoses / Antifungal Agents Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Postoperative Complications / Fluconazole / Follow-Up Studies / Treatment Outcome / Hematopoietic Stem Cell Transplantation / Therapeutic Uses / Administration, Intravenous / Voriconazole / Mycoses / Antifungal Agents Type of study: Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Hematology Year: 2014 Type: Article