A clinicopathological study of Castleman's disease / 中华病理学杂志
Chinese Journal of Pathology
; (12): 521-524, 2003.
Article
in Zh
| WPRIM
| ID: wpr-242147
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the pathogenesis and the differential diagnosis of Castleman's disease.</p><p><b>METHODS</b>Histopathology, immunohistochemical staining and clinical courses of 26 cases of Castleman's disease (CD) were studied with follow-up study of 16 cases.</p><p><b>RESULTS</b>The present study included 6 cases of multicentric type, 20 cases of localized type in the clinical aspects and 19 cases with hyaline vascular type, 4 cases with plasma cell type, 3 cases with mixed type in the histologic aspect. The Multicentric type presented systemic lymphadenopathy, anemia, hyperglobulinemia, hepatosplenomegaly, skin changes, and lung disorder and kidney disfunction, of which 1 case died of respiratory and renal insufficiency. 13 of the 20 localized cases were of the hyaline vascular type, and with good prognosis. 7 of the 20 cases showed paraneoplastic pemphigus associated with hyperglobulinemia (4/7) and lung disease (5/7). The pathologic features composed of proliferation of the mantle zone B cell, follicular dendritic cell, plasma cell and small vessels. In immunohistochemical staining, kappa and lambda light chains were detected in each CD case.</p><p><b>CONCLUSIONS</b>Many diseases are similar to CD clinicopathologically. It is important to make differential diagnosis through pathological study. Castleman's disease is a lymphoproliferative disorder. The pathogenesis of this multicentric disorder may be associated with autoimmune disease.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
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General Surgery
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Immunohistochemistry
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Follow-Up Studies
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Castleman Disease
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Pemphigus
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Treatment Outcome
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Leukocyte Common Antigens
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Antigens, CD20
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Diagnosis, Differential
Type of study:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
Limits:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2003
Type:
Article