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Therapeutic effect of anti-anaphylaxis granule on chronic urticaria and its impact on serum levels of RANTES / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine ; (12): 925-928, 2009.
Article in Chinese | WPRIM | ID: wpr-242364
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic effect of Anti-anaphylaxis Granule (AAG) on chronic urticaria and its impact on cytokine of regulated upon activation of normal T cells expressed and secreted (RANTES), eosinophil chemotactic factor (Eotaxin) and tumor necrosis factor-alpha (TNF-alpha).</p><p><b>METHODS</b>The therapeutic effects of AAG and cetirizine on chronic urticaria patients allocated in two groups were observed respectively, and the serum levels of RANTES, Eotaxin and TNF-alpha in patients were measured by ELISA before and after treatment, and were compared with those in normal subjects.</p><p><b>RESULTS</b>The therapeutic effects of AAG group were better in effective rate (88.5% vs 64.0%) and lower in the recurrent rate (5.6% vs 41.9%) than those cetirizine (all P<0.05). Serum levels of RANTES, Eotaxin and TNF-alpha in patients were higher than those in normal subjects (P<0.01), and they could be significantly reduced after AAG treatment (P<0.01).</p><p><b>CONCLUSION</b>AAG has favorite effect for treatment of chronic urticaria, its regulation on serum levels of RANTES, Eotaxin and TNF-alpha may be the mechanism of action.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Urticaria / Blood / Drugs, Chinese Herbal / Tumor Necrosis Factor-alpha / Cetirizine / Chemokine CCL5 / Serum / Therapeutic Uses / Drug Therapy / Chemokine CCL11 Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Urticaria / Blood / Drugs, Chinese Herbal / Tumor Necrosis Factor-alpha / Cetirizine / Chemokine CCL5 / Serum / Therapeutic Uses / Drug Therapy / Chemokine CCL11 Limits: Adolescent / Adult / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Integrated Traditional and Western Medicine Year: 2009 Type: Article