Advances in microbial production of 5-aminolevulinic acid / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1214-1222, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-242488
ABSTRACT
5-Aminolevulinic acid is the key intermediate of the tetrapyrrole biosynthesis pathway in organisms and has broad application potentials. This review summarized and discussed recent progress in microbial production of 5-aminolevulinic acid, including screening, isolation and mutation of microbes to produce 5-aminolevulinic acid; microbial whole-cell transformation to synthesize 5-aminolevulinic acid depending on the C4 pathway; construction of high-yield 5-aminolevulinic acid producing strains by metabolic engineering. Finally, future research directions in microbial production of 5-aminolevulinic acid were addressed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rhodobacter sphaeroides
/
Escherichia coli
/
Metabolic Engineering
/
Genetics
/
Aminolevulinic Acid
/
Metabolism
/
Mutation
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2013
Type:
Article
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