Preparation and Biodistribution of Re-188 Sulfru Colloid / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 298-304, 1998.
Article
in Korean
| WPRIM
| ID: wpr-24249
ABSTRACT
PURPOSE:
We evaluated the usefulness of Re-188 sulfur colloid for radiation synovectomy and therapy of intraperitoneal metastasis. MATERIALS ANDMETHODS:
We investigated the labeling efficiency of Re-188 sulfur colloid on various conditions. The stability of Re-188 sulfur colloid was observed at room temperature for 24 h and in human serum and synovial fluid for 72 h. The particle size distribution of Re-188 sulfur colloid was rneasured by filtering with various pore size filters. Animal experiment was performed in mice and rabbits.RESULTS:
The labeling efficiency of Re-188 sulfur colloid was 64,5+/-5.8% (n=5) at the conditions of sodium thiosulfate 40 mg, EDTA Na2.2H2O 0,8 mg, KReO4 0.8 mg at pH l. After purification, the radiochemical purity was higher than 99%. The stability of Re-188 sulfur colloid was high (>99%) at room temperature for 24 h and in human serum and synovial fluid for 72 h. The particle size distribution of Re-188 sulfur colloid was 0.3% (10 micrometer). In mice, 1 h postinjection of Re-188 sulfur colloid into tail vein, uptakes in lung, liver and muscle were 37.30+/-5.36, 32.33+/-5.79, 6.60+/-0.02% 1D/organ respectively. After I.p. injection in rnice, the uptakes of extraperitonial organs of Re-188 sulfur colloid at 1 and 24 h were 0.1+/-0.1, 0.4+/-0.1% ID/organ, and the excretions through urine and feces (~70 h) were low (2.68+/-0.80, 0.95+/-0.17%). When Re-188 sulfur colloid was injected to synovial space of rabbit, the uptake in other organs except knee was very low.CONCLUSION:
Re-188 sulfur colloid showed high labeling efficiency, stability and potency for clinical use.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Particle Size
/
Sodium
/
Sulfur
/
Synovial Fluid
/
Veins
/
Edetic Acid
/
Colloids
/
Animal Experimentation
/
Feces
/
Hydrogen-Ion Concentration
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Nuclear Medicine
Year:
1998
Type:
Article
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