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Absence of gender disparity in short-term clinical outcomes in patients with acute ST-segment elevation myocardial infarction undergoing sirolimus-eluting stent based primary coronary intervention: a report from Shanghai Acute Coronary Event (SACE) Registry / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 782-788, 2010.
Article in English | WPRIM | ID: wpr-242569
ABSTRACT
<p><b>BACKGROUND</b>Randomized, controlled trials have demonstrated the superiority of sirolimus-eluting stent (SES) implantation during primary percutaneous coronary intervention (PCI), as opposed to bare-metal stents, in patients with ST-elevation myocardial infarction (STEMI). This study aimed to test the hypothesis that clinical benefits of SES treatment were independent of gender in this setting.</p><p><b>METHODS</b>A total of 2042 patients with STEMI undergoing SES-based primary PCI were prospectively enrolled into Shanghai Acute Coronary Event (SACE) registry (1574 men and 468 women). Baseline demographics, angiographic and PCI features, and in-hospital and 30-day major adverse cardiac events (MACE) were analyzed as a function of gender.</p><p><b>RESULTS</b>Compared with men, women were older and more frequently had hypertension, diabetes, and hypercholesterolemia. Use of platelet glycoprotein IIb/IIIa receptor inhibitor (GPI, 65.5% vs. 62.2%, P = 0.10) and procedural success rate (95.0% vs. 94.2%, P = 0.52) were similar in both genders. In-hospital death and MACE occurred in 3.8% and 7.6%, and 4.5% and 8.1% in the male and female patients, respectively (all P > 0.05). At 30-day follow-up, survival (94.3% vs. 93.8%, P = 0.66) and MACE-free survival (90.2% vs. 89.3%, P = 0.52) did not significantly differ between men and women. After adjustment for differences in patient demographics, angiographic and procedural features, there were no significant difference in either in-hospital (OR = 0.77, 95%CI of 0.48 to 1.22, P = 0.30) or 30-day mortality (OR = 1.28, 95%CI of 0.73 to 2.23, P = 0.38) between women and men.</p><p><b>CONCLUSION</b>Despite more advanced age and clustering of risk factors in women, female patients with STEMI treated by SES-based primary PCI had similar in-hospital and short-term clinical outcomes as their male counterparts.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Angioplasty, Balloon, Coronary / China / Registries / Sex Factors / Prospective Studies / Mortality / Sirolimus / Therapeutic Uses / Drug-Eluting Stents Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Chinese Medical Journal Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Therapeutics / Angioplasty, Balloon, Coronary / China / Registries / Sex Factors / Prospective Studies / Mortality / Sirolimus / Therapeutic Uses / Drug-Eluting Stents Type of study: Controlled clinical trial / Observational study / Prognostic study / Risk factors Limits: Aged / Aged80 / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Chinese Medical Journal Year: 2010 Type: Article