Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 730-733, 2010.
Article
in English
| WPRIM
| ID: wpr-242581
ABSTRACT
<p><b>BACKGROUND</b>Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. In order to investigate the molecular biologic mechanism of HCC's development, we studied the expressions of SE-1, CD105 and CD31 in tumor endothelial cells (TECs) of HCC and in the serum of rats.</p><p><b>METHODS</b>We analyzed the expressions of SE-1, CD31 and CD105 in rat HCC tumor tissues using immunohistochemistry (IHC). Twenty HCC bearing rats and eighteen normal rats were examined for the expressions of SE-1, CD31 and CD105 antigens in serum by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>SE-1, CD31 and CD105 antigens were detected both in HCC tissue and in normal liver tissue with higher expressions of CD31 and CD105 in HCC while the SE-1 antigen expression was higher in normal liver. Similarly, serum CD31 and CD105 in rats with HCC were significantly increased compared with normal rats (t = 2.8628, P = 0.0086; t = 4.4922, P < 0.0001, respectively). In contrast, SE-1 antigen in HCC rat serum was significantly decreased compared with normal rats (t = 3.4983, P = 0.0011).</p><p><b>CONCLUSION</b>SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rats, Inbred BUF
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
Immunohistochemistry
/
Antigens, CD
/
Chemistry
/
Carcinoma, Hepatocellular
/
Platelet Endothelial Cell Adhesion Molecule-1
/
Endothelial Cells
/
Allergy and Immunology
Limits:
Animals
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Type:
Article
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