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Antiviral effect of recombinant antibody to influenza virus HA antigen / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 337-340, 2002.
Article in Chinese | WPRIM | ID: wpr-242616
ABSTRACT
<p><b>OBJECTIVE</b>Study on the antiviral effect in vivo and in vitro of recombinant antibodies with neutralization activity to influenza virus HA antigen, IgG-IV-2 and IgG-IV-6 obtained from expression in Baculo/insert system.</p><p><b>METHODS</b>Viral titer of influenza virus in MDCK was compared before and after antibody application, and measured viral titer in mouse lung before and after antibodies applied on mucous membrane.</p><p><b>RESULTS</b>IgG-IV-2 and IgG-IV-6 could reduce the titer from 4.5 log10 TCID50 to half is by 50% at doses 0.8 microg and 0.5 microg respectively. When recombinant antibodies were used on mucous membrane, the IgG-IV-2 and IgG-IV-6 reduced the titer by half at doses 0.25 mg/kg weight and 0.1 mg/kg weight respectively. The dose was 0.08 mg/kg weight when the two antibodies were jointly used.</p><p><b>CONCLUSIONS</b>The recombinant antibodies have antiviral effect in vivo and in vitro, they can neutralize viral virulence.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Influenza A virus / Neutralization Tests / Cell Line / Orthomyxoviridae Infections / Allergy and Immunology / Mice, Inbred BALB C / Antibodies, Monoclonal / Antibodies, Viral / Antibody Specificity / Antigens, Viral Limits: Animals Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Influenza A virus / Neutralization Tests / Cell Line / Orthomyxoviridae Infections / Allergy and Immunology / Mice, Inbred BALB C / Antibodies, Monoclonal / Antibodies, Viral / Antibody Specificity / Antigens, Viral Limits: Animals Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2002 Type: Article