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Serum levels of CC-Chemokine ligand 18 in the patients with pneumoconiosis / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 678-680, 2012.
Article in Chinese | WPRIM | ID: wpr-242764
ABSTRACT
<p><b>OBJECTIVE</b>To measure the peripheral serum levels of CC-chemokine ligand-18 (CCL-18) in patients with pneumoconiosis, and to investigate the feasibility of the index asa potential biomarker for pneumoconiosis.</p><p><b>METHODS</b>Seventy-seven male patients with pneumoconiosis (stage 140 cases, stage 222 cases, stage 315 cases), including 42 cases of silicosis and 35 cases of coal worker pneumoconiosis, were enrolled as subjects, and 162 healthy male physical examinees in our hospital were used as controls. A fasting blood sample (3 ml) was collected from the peripheral venous blood of each patient or control. The CCL-18 concentration in serum was measured by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The serum CCL-18 concentrations of the patients with pneumoconiosis were significantly higher than those of the controls [(116.70 ± 82.85) ng/ml vs. (83.34 ± 64.83) ng/ml]; (Z = -2.389, P < 0.05). The serum CCL-18 concentrations of the patients with silicosis were significantly higher than those of the patients with coal worker pneumoconiosis (147.02 ± 93.32 ng/ml vs. 96.43 ± 47.19 ng/ml; Z = -3.030, P < 0.05). There were no significant differences in serum CCL-18 concentration among different stages of pneumoconiosis (P > 0.05). The degree of respiratory impairment was positively correlated with the serum CCL-18 concentration in patients with pneumoconiosis (r = 0.611, P < 0.01).</p><p><b>CONCLUSION</b>Serum CCL-18 level can be used as a potential biomarker for pneumoconiosis.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumoconiosis / Blood / Case-Control Studies / Epidemiology / Chemokines, CC Type of study: Observational study Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pneumoconiosis / Blood / Case-Control Studies / Epidemiology / Chemokines, CC Type of study: Observational study Limits: Humans / Male Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2012 Type: Article