The Influence of Diabetes on of PGE2, MMP-14 and TIMP Expressions in Human Chronic Periodontitis / 대한치주과학회지
The Journal of the Korean Academy of Periodontology
;
: 755-766, 2007.
Article
in Korean
| WPRIM
| ID: wpr-24278
ABSTRACT
PURPOSE:
The purposes of this study were to compare and quantify the expression of PGE2, MMP-14 and TIMP-1 in the gingival tissues of patients with type 2 diabetes mellitus and healthy adults of chronic periodontitis with alveolar bone resorption. MATERIALS ANDMETHODS:
Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was devided into three groups. Group 1 (n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2 (n=8) is inflammed gingiva from patients of chronic periodontitis with alveolar bone resorption. Group 3 (n=8) is inflammed gingiva from patients of chronic periodontitis with alveolar bone resorption associated with type 2 diabetes. Tissue samples were prepared and analyzed by Western blotting. The quantification of PGE2, MMP-14 and TIMP-1 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test.RESULTS:
The expressions of MMP-14 and TIMP-1 were showed increasing tendency in group 2 & 3 compared to group 1. The expressions of PGE2, MMP-14 were showed increasing tendency in group 3 compared to group 1 and group 2. According to MMP-14 levels were increasing, PGE2 showed increasing tendency in group 3, and although PGE2, MMP-14 levels were increasing, TIMP-1 levels were similar expressed comparing to group 2.CONCLUSION:
In conclusion, this study demonstrated that the expression levels of MMP-14 and TIMP-1 had increasing tendency in inflammed tissue. It can be assumed that PGE2 and MMP-14 may be partly involved in alveolar bone resorptive process and the progression of periodontal inflammation associated to type 2 DM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Periodontal Pocket
/
Tooth Extraction
/
Bone Resorption
/
Dinoprostone
/
Blotting, Western
/
Tissue Inhibitor of Metalloproteinase-1
/
Diabetes Mellitus, Type 2
/
Chronic Periodontitis
/
Gingiva
/
Hemorrhage
Limits:
Adult
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Academy of Periodontology
Year:
2007
Type:
Article
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