Efficacy of Topical Tacrolimus for Erosive Oral Lichen Planus: A Meta-analysis / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 210-217, 2015.
Article
in English
| WPRIM
| ID: wpr-242819
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy and safety of topical tacrolimus for erosive oral lichen planus (EOLP).</p><p><b>METHODS</b>Literatures published up to December 2013 were searched from PubMed, Embase, CENTRAL, Chinese BioMedical Literature Database (CBM), and System for Information on Grey Literature in Europe (SIGLE). All randomized controlled trials (RCTs) of topical tacrolimus for EOLP which compared with other interventions or a placebo were considered in this Meta-analysis. Two researchers collected data independently. The assessment of methodological quality was based on Cochrane Handbook and the materials were analyzed with the software Revman 5.2.5. The primary outcome measures were the symptoms (e.g. pain, discomfort) complained by patients. The secondary outcome measures included the improvement rate of clinical signs assessed by the investigators and the incidence of adverse effects (e.g. clinical candidiasis).</p><p><b>RESULTS</b>A total of 9 RCTs involving 476 patients were finally included. The pooled odds ratio (OR) of clinical improvement for topical tacrolimus vs. topical corticosteroids was 1.19 [95% confidence interval (CI) 0.64-2.22, I2 44%]. Regarding to 0.1% tacrolimus and 0.03% tacrolimus, the pooled OR were 1.87 (95% CI 0.60-5.82) and 1.47 (95% CI 0.14-16.04) respectively in subgroup analysis. No serious adverse events were reported in topical tacrolimus group.</p><p><b>CONCLUSIONS</b>There was no evidence to support that topical tacrolimus for EOLP was more effective and safer than topical corticosteroids in this Meta-analysis. Clinical assessment criteria should be established and accepted by clinicians and researchers before further RCTs are undertaken.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Randomized Controlled Trials as Topic
/
Administration, Topical
/
Tacrolimus
/
Lichen Planus, Oral
/
Drug Therapy
/
Immunosuppressive Agents
Type of study:
Controlled clinical trial
/
Systematic reviews
Limits:
Humans
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2015
Type:
Article
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