Impact of 1, 25-(OH)2D3 on Left Ventricular Hypertrophy in Type 2 Diabetic Rats / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
; (4): 114-120, 2015.
Article
in En
| WPRIM
| ID: wpr-242835
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WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the impact of 1, 25-(OH)2D3 on left ventricular hypertrophy (LVH) in type 2 diabetic rats.</p><p><b>METHODS</b>Type 2 diabetic mellitus (DM) model rats were established by intraperitoneally injecting with 30 mg/kg streptozotocin. After 8 weeks, 19 male rats were identified as diabetic with left ventricular hypertrophy (LVH) by ultrasound examination, and randomly assigned into three groups: untreated (DM-LVH, n=7), treated with insulin (DM-LVH+INS, n=6), and treated with 1, 25-(OH)2D3 (DM-LVH+VD, n=6). Healthy male rats were used as the controls group (n=6). The fasting blood glucose and the insulin level were determined weekly. The left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor level were determined by 4 weeks later.</p><p><b>RESULTS</b>In the DM-LVH model group, the insulin level was significantly decreased compared with the non-diabetic control group (P<0.05), whereas the blood glucose, left ventricular mass index, myocardial collagen content, collagen volume fraction, and 1, 25-(OH)2D3-receptor expression were significantly increased (all P<0.05). In the DM-LVH+INS and DM-LVH+VD groups, the insulin levels were significantly increased compared with the DM-LVH model group (P<0.05), whereas the other parameters were significantly decreased (all P<0.05).</p><p><b>CONCLUSION</b>1, 25-(OH)2D3 could reverse LVH in diabetic rats and that the mechanism may involve stimulating insulin secretion and reducing blood glucose via direct up-regulation of 1, 25-(OH)2D3-receptor expression.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood
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Blood Glucose
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Calcitriol
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Rats, Wistar
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Hypertrophy, Left Ventricular
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Streptozocin
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Receptors, Calcitriol
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Therapeutic Uses
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Diabetes Mellitus, Experimental
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Diabetes Mellitus, Type 2
Limits:
Animals
Language:
En
Journal:
Chinese Medical Sciences Journal
Year:
2015
Type:
Article