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Factors associated with coronary artery disease in young population (age ≤ 40): analysis with 217 cases / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal ; (4): 38-42, 2014.
Article in English | WPRIM | ID: wpr-242903
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relevant factors of coronary artery disease (CAD) in young people under 40 years of age.</p><p><b>METHODS</b>The study population was 292 young patients accepting coronary angiography in Fuwai Hospital from July to December 2006, including 272 men and 20 women, with the mean age being 36.7 ± 3.7 years. The diagnosis of CAD was made in the cases presenting ≥ 50% stenosis in coronary lumen in coronary angiography. Based on the diagnosis, 217 patients (204 men, 13 women) were assigned to CAD group, and 75 (68 men, 7 women) to non-CAD group. Clinical data and metabolic characteristics of the patients were collected and analyzed using t-test, χ² test, and multinomial logistic regression with SPSS 8.0 software.</p><p><b>RESULTS</b>Most study subjects were current smokers (209/292, 71.6%), and more than half had body mass index (BMI)>24 kg/m² (230/292, 78.8%) and usually took high-fat diet (162/292, 55.5%). The proportion of heavy smokers (smoking history ≥ 10 years and ≥ 20 cigarettes per day) were significantly higher in the CAD group than in the non-CAD group [20.7% (45/217) vs. 9.3% (7/75), P=0.015)]. Heavy smoking [odds ratio (OR), 1.89; 95% confidence interval (CI), 1.74-2.05], hypertension (OR, 1.56; 95% CI, 1.48-1.65), alcohol (OR, 1.37; 95% CI, 1.30-1.46), type 2 diabetes mellitus (OR, 1.37; 95% CI, 1.25-1.50), high-fat diet (OR, 1.35; 95% CI, 1.28-1.43), and BMI>24 kg/m² (OR, 1.09; 95% CI, 1.03-1.17) were factors related to CAD in the young patients (all P<0.05). Total cholesterol (4.56 ± 1.46 mmol/L vs. 4.09 ± 1.00 mmol/L), low-density lipoprotein cholesterol (2.38 ± 1.11 mmol/L vs. 2.14 ± 0.63 mmol/L), lipoprotein a (134.97 ± 109.70 mg/L vs. 101.58 ± 58.39 mg/L), uric acid (359.89 ± 100.09 μmol/L vs. 336.75 ± 94.36 μmol/L), erythrocyte sedimentation rate (9.98 ± 12.19 mm/hour vs. 4.89 ± 4.92 mm/hour), high-sensitivity C-reactive protein (3.42 ± 4.39 mg/L vs. 2.80 ± 3.77 mg/L) and Big endothelin-1 (1.41 ± 1.50 fmol/mL vs. 0.77 ± 1.13 fmol/mL) in plasma were significantly increased in the CAD group compared with the non-CAD group (all P<0.05).</p><p><b>CONCLUSIONS</b>Heavy smoking, hypertension, alcohol consumption, type 2 diabetes mellitus, high-fat diet and BMI>24 kg/m² were significantly related to CAD in patients aged ≤ 40, with heavy smoking presenting the highest OR. Metabolic syndrome and inflammation were also more common in young CAD patients than in non-CAD patients.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Alcohol Drinking / Diagnostic Imaging / Angiography / Smoking / Logistic Models / China / Medical Records / Epidemiology / Retrospective Studies Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Chinese Medical Sciences Journal Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Coronary Artery Disease / Alcohol Drinking / Diagnostic Imaging / Angiography / Smoking / Logistic Models / China / Medical Records / Epidemiology / Retrospective Studies Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study / Risk factors Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Chinese Medical Sciences Journal Year: 2014 Type: Article