Effects of C-reactive protein on chemotaxis ability of monocytes in vitro / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 673-675, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-242922
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of C-reactive protein (CRP) on monocytes chemotaxis ability in vitro.</p><p><b>METHODS</b>Transwell chemotaxis assay was used to evaluate the changes of chemotactic ability of THP-1 monocytes in each group treated with CRP in different concentration.</p><p><b>RESULTS</b>CRP increased the number of attracted monocytes in response to MCP-1 (monocyte chemoattractant protein-1). When treated with CRP concentration at 2 microg x mL(-1), the number of chemotactic monocytes increased (P < 0.05). The number of attracted monocytes increased as CRP concentration was elevated (P < 0.05).</p><p><b>CONCLUSION</b>CRP can increase chemotactic ability of THP-1 monocytes in concentration dependent manner.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
In Vitro Techniques
/
C-Reactive Protein
/
Monocytes
/
Chemotaxis
/
Chemokine CCL2
Limits:
Humans
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2009
Type:
Article
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