Effects of tumor necrosis factor-alpha on the growth of rat osteoblasts / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 378-380, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-242999
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of tumor necrosis factor alpha (TNF-alpha) on the growth of rat osteoblasts. To find out the mechanisms that TNF-alpha regulates the growth of osteoblasts.</p><p><b>METHODS</b>To assay osteoblasts proliferation by MTT. To assay alkaline phosphatase (ALP) activity of osteoblasts by PP-nitrophenyl phosphate (PNPP).</p><p><b>RESULTS</b>The osteblasts proliferation and the ALP activity decreased in treatment groups, and the significantly lower levels were observed in above 50 ng/mL groups (P<0.05).</p><p><b>CONCLUSION</b>TNF-alpha restrained osteoblasts proliferation and differentiation, and the effects were more significant in above 50 ng/mL groups.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Cell Differentiation
/
Tumor Necrosis Factor-alpha
/
Cell Proliferation
/
Alkaline Phosphatase
Limits:
Animals
Language:
Chinese
Journal:
West China Journal of Stomatology
Year:
2009
Type:
Article
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