Effects of clotrimazole on the growth of oral squamous cell carcinoma / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>to investigate the effects of clotrimazole on the growth of oral squamous cell carcinoma (OSCC).</p><p><b>METHODS</b>OSCC-25 cells growing in log phase were treated with various doses of clotrimazole. The concentration of IC(50), cell cycle and cell cycle related protein were examined.</p><p><b>RESULTS</b>the concentration of clotrimazole for inhibiting OSCC was IC(50) 8.51 µmol/L. Clotrimazole induced cell cycle arrest in the G(0)-G(1) cell cycle phase, with a concomitant decrease of cells in the G(2)-M and S-phase. Furthermore, clotrimazole significantly decreased the levels of cyclin D, cyclin E and CDK-4.</p><p><b>CONCLUSIONS</b>clotrimazole inhibits the growth of OSCC.</p>