Epigenetic mechanism of RUNX1 in pathogenesis of leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 525-530, 2010.
Article
in Zh
| WPRIM
| ID: wpr-243320
Responsible library:
WPRO
ABSTRACT
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
Full text:
1
Index:
WPRIM
Main subject:
Leukemia
/
Protein Processing, Post-Translational
/
Epigenesis, Genetic
/
Core Binding Factor Alpha 2 Subunit
/
Genetics
/
Metabolism
Type of study:
Etiology_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article