Effect of Volatile Oil of Radix Angelicae Sinensis on experimental asthma in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 107-110, 2015.
Article
in Zh
| WPRIM
| ID: wpr-243407
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Volatile Oil of Radix Angelicae Sinensis (VOA) on experimental asthma in rat model based on abnormal immune functions of Treg cells.</p><p><b>METHODS</b>After grouping, the asthmatic rats were developed through injecting OVA and AI(OH)3 for sensitization and then administering OVA aerosol for challenge, and the respiratory functions, asthmatic behaviors, IL-10 levels in bronchoalveolar lavage fluid (BALF) (ELISA) and Foxp3 expression (immunohistochemistry) in lung of asthmatic rats were observed.</p><p><b>RESULTS</b>VOA at the doses of 40-160 mg/kg could improve the respiratory functions and the asthmatic behaviors, and upgrade IL-10 levels in BALF and Foxp3 expression in lung of asthmatic rats.</p><p><b>CONCLUSION</b>VOA has some effects of anti-asthma and one of the mechanisms is to improving the lower immune functions of Treg cells.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pharmacology
/
Asthma
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Plant Oils
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Oils, Volatile
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Bronchoalveolar Lavage Fluid
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Chemistry
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Interleukin-10
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T-Lymphocytes, Regulatory
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Angelica sinensis
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Cell Biology
Type of study:
Prognostic_studies
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2015
Type:
Article