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Effect of 5-HT1A receptors in the hippocampal DG on active avoidance learning in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 44-48, 2015.
Article in Chinese | WPRIM | ID: wpr-243436
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of serotonin (5-HTIA) receptors in the hippocampal dentate gyrus (DG) on active avoidance learning in rats.</p><p><b>METHODS</b>Totally 36 SD rats were randomly divided into control group, antagonist group and agonist group(n = 12). Active avoidance learning ability of rats was assessed by the shuttle box. The extracellular concentrations of 5-HT in the DG during active avoidance conditioned reflex were measured by microdialysis and high performance liquid chromatography (HPLC) techniques. Then the antagonist (WAY-100635) or agonist (8-OH-DPAT) of the 5-HT1A receptors were microinjected into the DG region, and the active avoidance learning was measured.</p><p><b>RESULTS</b>(1) During the active avoidance learning, the concentration of 5-HT in the hippocampal DG was significantly increased in the extinction but not establishment in the conditioned reflex, which reached 164.90% ± 26.07% (P <0.05) of basal level. (2) The microinjection of WAY-100635 (an antagonist of 5-HT1A receptor) into the DG did not significantly affect the active avoidance learning. (3) The microinjection of 8-OH-DPAT(an agonist of 5-HT1A receptor) into the DG significantly facilitated the establishment process and inhibited the extinction process during active avoidance conditioned reflex.</p><p><b>CONCLUSION</b>The data suggest that activation of 5-HT1A receptors in hipocampal DG may facilitate active avoidance learning and memory in rats.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Piperazines / Pyridines / Avoidance Learning / Serotonin / 8-Hydroxy-2-(di-n-propylamino)tetralin / Serotonin Receptor Agonists / Rats, Sprague-Dawley / Dentate Gyrus Limits: Animals Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Physiology / Piperazines / Pyridines / Avoidance Learning / Serotonin / 8-Hydroxy-2-(di-n-propylamino)tetralin / Serotonin Receptor Agonists / Rats, Sprague-Dawley / Dentate Gyrus Limits: Animals Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2015 Type: Article