Decreased expression of calcium-sensing receptor involved in the progression of diabetic cardiomyopathy / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 35-37, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-243439
ABSTRACT
<p><b>OBJECTIVE</b>To observe the dynamic expression of calcium-sensing receptor(CaSR) in myocardium of diabetic rats.</p><p><b>METHODS</b>Thirty male Wistar rats were randomly divided into 3 groups including control, diabetic-4 week and diabetic-8 week groups(n = 10). The type 2 diabetes mellitus models were established by intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) after high-fat and high-sugar diet for one month. The cardiac morphology was observed by electron microscope. Western blot analyzed the expression of CaSR, phospholamban (PLN), a calcium handling regulator, and Ca+-ATPase(SERCA) in cardiac tissues.</p><p><b>RESULTS</b>Compared with control group, the expressions of CaSR and SERCA were decreased, while the expression of PLN was significantly increased in a time-dependent manner in diabetic groups. Meanwhile diabetic rats displayed abnormal cardiac structure.</p><p><b>CONCLUSION</b>These results indicate that the CaSR expression of myocardium is reduced in the progression of DCM, and its potential mechanism may be related to the imnaired intracellular calcium homeostasis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Calcium-Binding Proteins
/
Rats, Wistar
/
Streptozocin
/
Disease Progression
/
Receptors, Calcium-Sensing
/
Diabetes Mellitus, Experimental
/
Diabetes Mellitus, Type 2
/
Sarcoplasmic Reticulum Calcium-Transporting ATPases
/
Diabetic Cardiomyopathies
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS