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Decreased expression of calcium-sensing receptor involved in the progression of diabetic cardiomyopathy / 中国应用生理学杂志
Chinese Journal of Applied Physiology ; (6): 35-37, 2015.
Article in Chinese | WPRIM | ID: wpr-243439
ABSTRACT
<p><b>OBJECTIVE</b>To observe the dynamic expression of calcium-sensing receptor(CaSR) in myocardium of diabetic rats.</p><p><b>METHODS</b>Thirty male Wistar rats were randomly divided into 3 groups including control, diabetic-4 week and diabetic-8 week groups(n = 10). The type 2 diabetes mellitus models were established by intraperitoneal injection of streptozotocin (STZ, 30 mg/kg) after high-fat and high-sugar diet for one month. The cardiac morphology was observed by electron microscope. Western blot analyzed the expression of CaSR, phospholamban (PLN), a calcium handling regulator, and Ca+-ATPase(SERCA) in cardiac tissues.</p><p><b>RESULTS</b>Compared with control group, the expressions of CaSR and SERCA were decreased, while the expression of PLN was significantly increased in a time-dependent manner in diabetic groups. Meanwhile diabetic rats displayed abnormal cardiac structure.</p><p><b>CONCLUSION</b>These results indicate that the CaSR expression of myocardium is reduced in the progression of DCM, and its potential mechanism may be related to the imnaired intracellular calcium homeostasis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Calcium-Binding Proteins / Rats, Wistar / Streptozocin / Disease Progression / Receptors, Calcium-Sensing / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Sarcoplasmic Reticulum Calcium-Transporting ATPases / Diabetic Cardiomyopathies Limits: Animals Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Calcium-Binding Proteins / Rats, Wistar / Streptozocin / Disease Progression / Receptors, Calcium-Sensing / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 2 / Sarcoplasmic Reticulum Calcium-Transporting ATPases / Diabetic Cardiomyopathies Limits: Animals Language: Chinese Journal: Chinese Journal of Applied Physiology Year: 2015 Type: Article