Efficacy and safety of combination therapy with simvastatin and fenofibrate for combined hyperlipidemia / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 122-126, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-243497
ABSTRACT
<p><b>OBJECTIVE</b>The aim of this study was to evaluate the efficacy and safety of combination therapy with simvastatin and fenofibrate in patients with combined hyperlipidemia.</p><p><b>METHODS</b>A total of 221 patients with combined hyperlipidemia were randomly assigned to receive 10 mg simvastatin (n = 72) or 200 mg fenofibrate (n = 68), or a combination of 10 mg simvastatin + 200 mg fenofibrate (n = 81) for 6 months. Lipid profiles, physical and laboratory investigations for adverse effects were assessed.</p><p><b>RESULTS</b>(1) Combination treatment were more effective in normalizing lipid profile than any monotherapy. Serum TC, LDL-C, and TG were reduced by 30%, 37% and 56% respectively, whilst HDL-C significantly increased by 24% (all P < 0.01). The improvement in TG and HDL-C achieved by combination treatment was superior to fenofibrate or simvastatin alone. (2) The success rate of TC, LDL-C and TG control in the combination therapy group were 51%, 55% and 61% respectively, with an overall success rate (all three together) of 45%, which was superior to either drug given as monotherapy. (3) All treatments were well tolerated with no increase in adverse events for combination therapy versus monotherapy.</p><p><b>CONCLUSION</b>The results of this study demonstrated that combination therapy with fenofibrate (200 mg/day) and low-dose simvastatin (10 mg/day) is more effective than monotherapy in patients with combined hyperlipidemia, and is generally safe and well tolerated.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Fenofibrate
/
Simvastatin
/
Therapeutic Uses
/
Drug Therapy
/
Drug Therapy, Combination
/
Hyperlipoproteinemia Type V
/
Hypolipidemic Agents
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2005
Type:
Article
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