Evaluation of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with magnetic resonance imaging and proton magnetic resonance spectroscopy / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 234-238, 2006.
Article
in English
| WPRIM
| ID: wpr-243578
ABSTRACT
<p><b>OBJECTIVE</b>To study the characteristics of spectra on proton magnetic resonance spectroscopy (1H-MRS) and its value in patients with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS).</p><p><b>METHODS</b>Seven clinically diagnosed patients with MELAS underwent magnetic resonance imaging (MRI) and 1H-MRS examinations. The 1H-MRS techniques, characteristics of the spectra, and its correlation with the laboratory tests were analyzed.</p><p><b>RESULTS</b>Cerebral abnormalities were revealed in all 7 patients on conventional MR images, and most abnormal signals were observed in bilateral occipital, parietal, and temporal lobes. We found 4 cases with basal ganglia involvement, 2 cases with mild frontal lobe lesions, and 1 case with involvement of lateral cerebral peduncles and thalami. Additionally, 1 patient was involved with left insular lobe. Spectra from prominent lesions in brain parenchyma showed lactate doublet peak in 6 patients, 3 of whom were also noted lactate peak in ventricular cerebrospinal fluid (CSF).</p><p><b>CONCLUSION</b>1H-MRS may provide more direct information about the metabolism changes, which aids to affirm the diagnosis, and may replace the conventional invasive method of quantifying lactate in CSF.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parietal Lobe
/
Pathology
/
Basal Ganglia
/
Magnetic Resonance Imaging
/
Magnetic Resonance Spectroscopy
/
Cerebral Cortex
/
MELAS Syndrome
/
Lactic Acid
/
Diagnosis
/
Metabolism
Type of study:
Diagnostic study
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2006
Type:
Article
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