Experimental study on plasticity of proliferated neural stem cells in adult rats after cerebral infarction / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 184-188, 2006.
Article
in English
| WPRIM
| ID: wpr-243590
ABSTRACT
<p><b>OBJECTIVE</b>To investigate whether there is endogenous neural stem cell proliferation and whether these proliferated neural stem cells represent neural plasticity in the adult rats after cerebral infarction.</p><p><b>METHODS</b>Cerebral infarction models of rats were established and the dynamic expression of bromodeoxyuridine (BrdU), BrdU/polysialylated neural cell adhesion molecule (PSA-NCAM) were determined by immunohistochemistry and immunofluorescence staining. BrdU was used to mark dividing neural stem cells. PSA-NCAM was used to mark the plasticity of neural stem cells.</p><p><b>RESULTS</b>Compared with controls, the number of BrdU-positive cells in the subventricular zone (SVZ) and hippocampus increased significantly at 1st day after cerebral infarction (P < 0.05), reached maximum at 7th day, decreased markedly at 14th day, but it was still elevated compared with that of the controls (P < 0.05). The number of BrdU-labeled with PSA-NCAM-positive cells increased significantly at 7th day (P < 0.05), reached maximum at 14th day, markedly decreased at 28th day, but it was still elevated compared with that of the controls (P < 0.05). It was equal to 60% of the number of BrdU-positive cells in the same period.</p><p><b>CONCLUSION</b>Cerebral infarction may stimulate the proliferation of endogenous neural stem cells in situ and most proliferated neural stem cells represent neural plasticity.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Sialic Acids
/
Stem Cells
/
Bromodeoxyuridine
/
Cerebral Infarction
/
Cerebral Ventricles
/
Rats, Wistar
/
Neural Cell Adhesion Molecule L1
/
Cell Proliferation
/
Hippocampus
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2006
Type:
Article
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