Effects of vitamin D receptor gene polymorphisms on susceptibility to type 1 diabetes mellitus / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 95-98, 2006.
Article
in English
| WPRIM
| ID: wpr-243610
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of vitamin D receptor (VDR) gene polymorphisms on susceptibility to type 1 diabetes mellitus (T1DM) in the Chinese Han population.</p><p><b>METHOD</b>One hundred and thirty-six Chinese Han people, including 54 T1DM patients and 82 unrelated healthy subjects as control were genotyped by polymerase chain reaction-restriction fragment length polymorphism for three restriction sites in the VDR gene, which were ApaI, TaqI, and BamI.</p><p><b>RESULTS</b>The frequency of B allele of BsmI site in VDR gene was significantly higher in T1DM patients than in healthy subjects (P = 0.033) while no difference was found between the two groups in the distribution of ApaI and TaqI polymorphisms.</p><p><b>CONCLUSION</b>The BsmI polymorphism of VDR gene may be associated with the susceptibility to T1DM in the Chinese Han population of Beijing.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Restriction Fragment Length
/
Base Sequence
/
Case-Control Studies
/
China
/
Receptors, Calcitriol
/
DNA Primers
/
Asian People
/
Diabetes Mellitus, Type 1
/
Gene Frequency
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2006
Type:
Article
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