Changes of interleukin-6 and related factors as well as gastric intramucosal pH during colorectal and orthopaedic surgical procedures / 中国医学科学杂志(英文版)
Chinese Medical Sciences Journal
;
(4): 57-61, 2006.
Article
in English
| WPRIM
| ID: wpr-243619
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes of perioperative serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and cortisol, as well as gastric intramucosal pH (pHi) and plasma lactate, aiming to compare systemic changes and tissue perfusion during colorectal and orthopaedic surgical procedures.</p><p><b>METHODS</b>Twenty patients were randomly assigned to two groups, 10 cases of operation on vertebral canal, 10 cases of colorectal radical operation. Venous blood was drawn at 1 day before operation, 2, 4, and 6 hours following skin incision, and 1 day after operation, in order to measure serum IL-6, CRP, and cortisol. pHi and plasma lactate were also measured at the same time points.</p><p><b>RESULTS</b>Serum concentrations of IL-6 and cortisol increased gradually following operation, reaching the peak value at 6 hours from the beginning of operation. CRP was not detectable until the first day after operation. Peak concentration of IL-6 had positive relationship with CRP. These variables changed more significantly in colorectal group than that in orthopaedic group (P < 0.05). pHi decreased gradually, reaching the lowest level at 4 hours from the beginning of operation, and to more extent in colorectal group than that in orthopaedic group (P < 0.05).</p><p><b>CONCLUSION</b>IL-6 may reflect tissue damage more sensitively than CRP. Colorectal surgery might induce systemic disorder to more extent, in terms of immuno-endocrinal aspect as well as tissue perfusion, reflected with pHi.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spinal Stenosis
/
General Surgery
/
Blood
/
C-Reactive Protein
/
Hydrocortisone
/
Colorectal Neoplasms
/
Interleukin-6
/
Lactic Acid
/
Perioperative Care
/
Gastric Acidity Determination
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Sciences Journal
Year:
2006
Type:
Article
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