Study of mutation and single nucleotide polymorphism of PDGFRbeta and SHIP gene in acute myeloid leukemia / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 383-385, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-243942
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the significance of mutation and single nucleotide polymorphism (SNP) of class III receptor tyrosine kinases such as PDGFRbeta and SHIP in acute myeloid leukemia (AML) patients.</p><p><b>METHODS</b>Screening of the mutation and SNP of PDGFRbeta and SHIP by genomic PCR, RT-PCR, directly sequencing and Mass-ARRAY system was carried out in 273 AML patients.</p><p><b>RESULTS</b>The mutations of PDGFRbeta R685C and SHIP Q1153L were detected for the first time in AML patients. The positivity ratio was 0.73% and 0.36% respectively.</p><p><b>CONCLUSION</b>The mutations of PDGFRbeta R685C and SHIP Q1153L may contribute to leukemogenesis of AML.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Leukemia, Myeloid, Acute
/
Polymerase Chain Reaction
/
Reverse Transcriptase Polymerase Chain Reaction
/
Receptor, Platelet-Derived Growth Factor beta
/
Polymorphism, Single Nucleotide
/
Genetics
/
Inositol Phosphates
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2006
Type:
Article
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