Natural killer-like T-cell lymphoma/leukemia--a case report and literature review / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 226-230, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-243969
ABSTRACT
<p><b>OBJECTIVE</b>To identify the clinical and pathological features of natural killer-like T-cell lymphoma/leukemia.</p><p><b>METHODS</b>The characteristics of natural killer-like T-cell lymphoma/leukemia was discussed with report a new case and review of literatures.</p><p><b>RESULTS</b>A 16-year-old girl was referred to our hospital because of fever and disseminated cutaneous herpes and ulcer. Atypical lymphoid cells surrounded the dermal vessels with a CD3(+), CD8(+), CD4(-), CD5(-), CD10(-), CD19(-), CD57(-), CD56(+), perforin(+), granzyme B(+) immunophenotype and rearranged T-cell receptor-gamma gene implicated natural killer-like T cell origin. She was treated with prednisone and for several months. Then the patient developed progressive spleen enlargement with overt leukemia, which led to her eventual death.</p><p><b>CONCLUSIONS</b>Natural killer-like T-cell lymphoma/leukemia is a rare disease with distinctive clinical, histopathologic, and immuno phenotypic characteristics. Current treatment modalities are ineffective for most of the patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Killer Cells, Natural
/
Leukemia, T-Cell
/
Lymphoma, T-Cell
/
CD56 Antigen
/
Allergy and Immunology
Type of study:
Prognostic study
Limits:
Adolescent
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2006
Type:
Article
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