Preliminary study on the safety and pharmacodynamic action of low dose L-asparaginase / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 14-16, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-244001
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the safety and therapeutic effect of low dose (1000 U/m(2)) L-asparaginase (L-Asp) in the treatment of children with acute lymphoblastic leukemia (ALL).</p><p><b>METHODS</b>Six patients were treated with low dose L-Asp after previously suffered severe side effects from standard dose L-Asp (5000 - 10,000 U/m(2)). Twenty-eight blood samples were obtained randomly from 5 of them. Plasma asparagine concentration was detected by reverse phase-high performance liquid chromatography (RP-HPLC).</p><p><b>RESULTS</b>All the patients treated with low dose L-Asp showed no any toxic symptoms. The plasma asparagine levels in the patients were all above 5 micromol/L except case 4 (4.91 micromol/L) before receiving L-Asp, and were all decreased below 0.5 micromol/L five days after receiving low dose L-Asp, except case 3 (3.70 micromol/L), the results being like that of receiving standard dose L-Asp.</p><p><b>CONCLUSION</b>Low dose L-Asp has definite efficacy for childhood ALL, while avoids serious side effects from standard dose L-Asp.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asparaginase
/
Blood
/
Treatment Outcome
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Antineoplastic Agents
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2006
Type:
Article
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