Vascular endothelial function in salt sensitive and non-salt sensitive subjects / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 61-64, 2011.
Article
in Zh
| WPRIM
| ID: wpr-244057
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Salt-sensitivity is associated with more severe target organ injury and higher mortality in patients with essential hypertension. We compared the vascular endothelial function between salt-sensitive subjects (SS) and non-salt-sensitive subjects (NSS) with normal or mildly increased blood pressure.</p><p><b>METHODS</b>Ninety-nine subjects (aged 16 - 60 years) with normal blood pressure or mild hypertension (degree 1) were enrolled. The test program included 3 days baseline investigation, 1 week low-salt loading phase and 1 week high-salt loading phase. Endothelial function was assessed by measuring the flow mediated dilatation (FMD) of the brachial artery using high resolution ultrasound.</p><p><b>RESULTS</b>There was 17.2% SS. Plasma NOx level [(61.2 ± 13.3) µmol/L vs (82.5 ± 14.6) µmol/L, P < 0.05] and FMD [(10.2 ± 2.5)% vs (14.5 ± 1.6)%, P < 0.05] were significantly lower in SS subjects than in NSS subjects.</p><p><b>CONCLUSION</b>Vascular endothelial dysfunction was evidenced in SS subjects with normal blood pressure or in the early stage of hypertension.</p>
Full text:
1
Index:
WPRIM
Main subject:
Blood Pressure
/
Endothelium, Vascular
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Sodium, Dietary
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Case-Control Studies
/
Endothelium
/
Metabolism
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
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Adult
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Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2011
Type:
Article