The Effectiveness of 6-month Treatment with Citalopram in Korean Panic Disorder Patients: A Prospective, Open-labeled, Multi-Center Trial / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 203-211, 2006.
Article
in Korean
| WPRIM
| ID: wpr-24414
ABSTRACT
OBJECTIVE:
The authors examined the efficacy of citalopram, and its effect on the quality of life in patients with panic disorder.METHOD:
Seventy three patients who had panic disorder were recruited for this study. They did not have major depression and other axis I diseases. They were scheduled to be examined 4 times (at baseline, 4, 12 and 24 weeks) and took citalopram for 24 weeks with a flexible dosing schedule. The primary efficacy variables were the response and remission rates (response HAMA total score decreased by at least 50% from baseline; remission HAMA total score < or = 7). Other variables included the Hamilton Rating Scale for Depression, Panic Disorder Severity Scale (PDSS), Acute Panic Inventory, Clinical Global Impression Scale and Sheehan Disabilities Scale (SDS).RESULTS:
The number of patients who completed 24 weeks of treatment was 33 (45.2%). Forty patients who were dropped out consisted of 4 patients with symptom improvement and 36 patients with failure to return. Response/remission rates were 56.2/31.5% in the last-observation-carried-forward methods and 87.9/69.7% in the observed case data. Treatment with citalopram improved anxiety and depressive symptoms during 24 weeks on all efficacy measures. By a completed patient analysis, citalopram also significantly improved the disability scores on SDS. In this study, any serious adverse effects were not observed.CONCLUSION:
Treatment with citalopram was effective and well-tolerated for the patients with panic disorder, and also improved quality of life in the patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Anxiety
/
Panic
/
Appointments and Schedules
/
Quality of Life
/
Axis, Cervical Vertebra
/
Citalopram
/
Prospective Studies
/
Treatment Outcome
/
Panic Disorder
/
Depression
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2006
Type:
Article
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