Evaluation of the myocardial systolic function and ventricular remodeling of rats with experimental myocardial infarction by strain/strain rate imaging and MMP-9 / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 597-600, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-244165
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the myocardial systolic function and ventricular remodeling in heart failure rat induced by myocardial infarction (MI) with S/SRI and MMP-9.</p><p><b>METHODS</b>A total of 70 male SD rats were randomly assigned to 4 groups 4 weeks and 8 weeks MI (anterior descending branch of left coronary artery were ligated), sham operation (thoracotomy without ligation of coronary artery) and non-operated control group. The regional myocardial systolic function of rats was quantified with S/SRI. The myocardial MMP-9 expression was detected by Western blot.</p><p><b>RESULTS</b>In the 4 weeks MI group, all segment's Ssys, SRsys, the strain of end-systole were reduced while PSI was increased compared to sham and non-operated group with the exception of the inferior wall. These changes were more significant in 8 weeks MI group compared to the 4 weeks MI group. In the 4 weeks MI group, the expression of MMP-9 was significantly upregulated than the sham operation group and this upregulation was more significant at 8 weeks post MI.</p><p><b>CONCLUSIONS</b>S/SRI can quantitative evaluate the regional systolic function of heart failure rat induced by myocardial infarction. Progressive upregulation of myocardial MMP-9 expression paralleled the deterioration of regional systolic function in this heart failure rat model.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Systole
/
Rats, Sprague-Dawley
/
Ventricular Remodeling
/
Matrix Metalloproteinase 9
/
Myocytes, Cardiac
/
Heart Failure
/
Metabolism
/
Myocardial Contraction
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2010
Type:
Article
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