Differences of Glucose and Lipid Metabolism among the Type of Antipsychotic Drugs in Schizophrenia Patients with Long-Term Use of Antipsychotic Drugs / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 181-187, 2006.
Article
in Korean
| WPRIM
| ID: wpr-24417
ABSTRACT
OBJECTIVE:
The development of metabolic disorders including diabetes mellitus and hyperlipidemia has been reported among schizophrenia patients treated with atypical antipsychotic drugs. The role of antipsychotic drugs in the development of this condition has not been proven yet. This study was conducted to investigate whether antipsychotic drugs that often induce weight gain influence glucose and lipid metabolism including insulin resistance and serum leptin level.METHODS:
The study population consisted of 63 patients (all meeting DSM-IV criteria for schizophrenia), who were divided into 3 treatment groups haloperidol (N=21), risperidone (N=21), and olanzapine (N=21) monotherapy, and 31 healthy control subjects. Fasting blood samples for glucose, insulin, leptin and lipids were analysed. In addition, insulin resistance (IR) was calculated through the homeostatic model assessment (HOMA) and body mass index (BMI) was also calculated.RESULTS:
In patients receiving olanzapine, significant increases in BMI (p<0.01) and lipid profiles including LDL-cholesterol (p<0.05), triglyceride (p<0.01) and leptin levels (p<0.001) were found in comparison with the normal control group. A significantly higher degree of IR, as measured with the HOMA index, was found in patients receiving olanzapine than in patients receiving haloperidol (p<0.01) and risperidone (p<0.05), and in the normal control group (p<0.01). After removal of the impacts of BMI on the degree of HOMA-IR and serum leptin levels, the degree of HOMA-IR (p<0.05) and serum leptin levels (p<0.001) was also higher in patients receiving olanzapine than in the normal control group.CONCLUSION:
The results of this study suggest that olanzapine has more significant influence on metabolic complications than haloperidol and risperidone and the characteristics of antipsychotic drug per se may be involved in the development of metabolic complication as well as weight change.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Antipsychotic Agents
/
Triglycerides
/
Insulin Resistance
/
Weight Gain
/
Body Mass Index
/
Fasting
/
Risperidone
/
Leptin
/
Diagnostic and Statistical Manual of Mental Disorders
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2006
Type:
Article
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