Study on the molecular biology of hemorrhagic fever virus in Xinjiang / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 449-452, 2002.
Article
in Zh
| WPRIM
| ID: wpr-244246
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the structure and function at molecular level and the routes of transmission of Xinjiang hemorrhagic fever (XHF) virus.</p><p><b>METHODS</b>S genes of five XHF virus strains were cloned, sequenced and compared with that of other Crimean-Congo hemorrhagic fever virus strains.</p><p><b>RESULTS</b>It was found that S genes of the five viruses had 1,672 nuclei tides, while ORF of them including 1,449 nuclei tides and coded with a protein of 482 amino acid. The nucleotides homology of Chinese isolates (93.0%-99.5%) was obviously higher than that of any other S genes strains identified in other countries'. Phylogenetic tree showed that all Chinese isolates clustered into one branch and could be further divided into another three groups.</p><p><b>CONCLUSION</b>The sequential difference of S genes was not totally related to the host, areas and time of the viruses isolated.</p>
Full text:
1
Index:
WPRIM
Main subject:
Phylogeny
/
Genetic Variation
/
Classification
/
Hemorrhagic Fever Virus, Crimean-Congo
/
Genes, Bacterial
/
Genetics
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2002
Type:
Article