JAK2 V617F positive essential thrombocythemia developing in a patient with CD5⁻ chronic lymphocytic leukemia / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2076-2079, 2012.
Article
in English
| WPRIM
| ID: wpr-244410
ABSTRACT
Coexistence of chronic lymphocytic leukemia (CLL) and essential thrombocythemia (ET) in a patient is extremely rare, with only 10 cases reported thus far in literature. This paper describes a 94-year-old male having atypical B-CLL with CD5⁻ (CD5⁻) phenotype and ET. In this patient, we performed interphase fluorescence in situ hybridization (FISH) analysis which revealed 13q14.3 deletion in 31% of B-lymphocyte nuclei and RB1 deletion in 27% of B-lymphocyte nuclei, but not in neutrophils and T-lymphocytes. Furthermore, we identified JAK2 V617F mutation in the peripheral blood nucleated cells and neutrophils, but not in the B- and T-lymphocyte populations. Therefore, it was concluded that the occurrence of CD5− B-CLL and ET in this patient was pathogenically independent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Lymphocytic, Chronic, B-Cell
/
In Situ Hybridization
/
CD5 Antigens
/
Janus Kinase 2
/
Genetics
/
Thrombocythemia, Essential
/
Metabolism
/
Mutation
Type of study:
Prognostic study
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2012
Type:
Article
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