Gram-negative resistance in Singapore: a historical perspective
Annals of the Academy of Medicine, Singapore
;
: 847-854, 2008.
Article
in English
| WPRIM
| ID: wpr-244480
ABSTRACT
In the past 3 decades, classical extended-spectrum beta-lactamases (ESBLs) have probably been the main contributors to gram-negative antimicrobial resistance in Singapore. These appear to be being replaced by the newer CTX-M ESBLs. Metallo-beta-lactamases are found in Pseudomonas aeruginosa but do not seem to have spread widely in Acinetobacter spp. and Enterobacteriaceae. Carbapenem-hydrolysing oxacillinases are prevalent in multidrug-resistant Acinetobacter spp. More insidious developments include the emergence of plasmid AmpC beta-lactamases and multifactorial quinolone resistance in Enterobacteriaceae.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Singapore
/
Beta-Lactamases
/
Drug Resistance, Microbial
/
Microbial Sensitivity Tests
/
Carbapenems
/
Cephalosporins
/
Quinolones
/
History, 20th Century
/
History, 21st Century
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Annals of the Academy of Medicine, Singapore
Year:
2008
Type:
Article
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