Effect of substance P on cardiac autonomic nervous function in rats / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1320-1324, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-244635
ABSTRACT
<p><b>UNLABELLED</b>Forty SD rats were divided into 5 groups control group, SP groups (5 microg/kg,10 microg/kg, 20 microg/kg) and spantide II plus SP group. An analysis of heart rate variability (HRV) was used to detect the changes of HRV parameters before and after intravenous injection of SP in order to investigate the effect of substance P on cardiac autonomic nervous function and the corresponding mechanism.</p><p><b>RESULTS</b>(1) There were significant differences in most HRV parameters for the three different doses of SP. Mean heart period (MHP), absolute power of ultra-low frequency and high frequency band (APU, APH), total power (TPV) and ratio of power in ultra-low to high frequency band (RUH) increased, while mean heart rate (MHR) and chaos intensity (HCC) decreased during the 30 minutes. Each peak amplitude of HRV parameters went higher and showed up ahead of the upward doses of SP. (2) Significant change was seen in each of the parameters between spantide II plus SP group and high-dose SP group. These data idicate that, after intravenous injection of different doses of SP, both cardiac sympathetic nervous system activity and parasympathetic nervous system activity increase, and the function of cardiac autonomic nervous becomes instable and unbalanced. The effect of SP may be dose dependent, and it is possibly mediated by neurokinin-1(NK-1) receptor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Autonomic Nervous System
/
Substance P
/
Rats, Sprague-Dawley
/
Receptors, Neurokinin-1
/
Heart Conduction System
/
Heart Rate
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2009
Type:
Article
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