Lentinan induces the expression of human-beta-defensin-2 in pulmonary epithelial cells

Yan ZHOU; Birong DONG; Lihua TENG; Hui WANG

Lentinan induces the expression of human-beta-defensin-2 in pulmonary epithelial cells / 生物医学工程学杂志

Yan ZHOU; Birong DONG; Lihua TENG; Hui WANG.

Journal of Biomedical Engineering ; (6): 1311-1314, 2009.

Article in Chinese | WPRIM | ID: wpr-244637

ABSTRACT

ABSTRACT

To determine whether lentinan could upregulate the expression of human-beta-defensin-2(HBD-2) in pulmonary epithelial cells (SPC-A-1), we stimulated pulmonary epithelial cells with lentinan and detected the expression of HBD-2mRNA by RT-PCR test. The results demonstrated that the expression of HBD-2mRNA in SPC-A-1 could be induced by lentinan in a concentration and time-dependent manner.

Subject(s)

Humans; Adjuvants, Immunologic; Pharmacology; Epithelial Cells; Metabolism; Lentinan; Pharmacology; Lung; Cell Biology; Metabolism; RNA, Messenger; Genetics; Metabolism; beta-Defensins; Genetics; Metabolism

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / RNA, Messenger / Adjuvants, Immunologic / Beta-Defensins / Cell Biology / Epithelial Cells / Genetics / Lentinan / Lung / Metabolism Limits: Humans Language: Chinese Journal: Journal of Biomedical Engineering Year: 2009 Type: Article

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