Study advancement of calpain and apoptosis following cerebral ischemia

Jian LIU; Junfeng XU; Guangjun WANG; Mingxing YANG; Lin GUO

Study advancement of calpain and apoptosis following cerebral ischemia / 生物医学工程学杂志

Jian LIU; Junfeng XU; Guangjun WANG; Mingxing YANG; Lin GUO.

Journal of Biomedical Engineering ; (6): 1150-1153, 2009.

Article in Chinese | WPRIM | ID: wpr-244672

ABSTRACT

ABSTRACT

Calpains, calcium-activated cysteine proteases with a neutral pH optimum, lead to degration of cystoskeletion and structural protein, and delayed neuronal death. The activation of calpains contribute to apoptosis. Calpain inhibitors provide a novel and potential treatment for cerebral ischemia due to improvement of cerebral infarct and ischemia.

Subject(s)

Animals; Humans; Apoptosis; Brain Ischemia; Drug Therapy; Metabolism; Calcium-Binding Proteins; Therapeutic Uses; Calpain; Metabolism; Physiology

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Calcium-Binding Proteins / Calpain / Brain Ischemia / Apoptosis / Therapeutic Uses / Drug Therapy / Metabolism Limits: Animals / Humans Language: Chinese Journal: Journal of Biomedical Engineering Year: 2009 Type: Article

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