Clinical features of catheter-related candidemia at disease onset
Singapore medical journal
;
: 579-582, 2014.
Article
in English
| WPRIM
| ID: wpr-244737
ABSTRACT
<p><b>INTRODUCTION</b>Early detection of catheter-related candidemia is necessary to ensure that patients receive prompt and appropriate treatment. The aim of the present case-control study is to investigate the clinical features of catheter-related candidemia at disease onset, so as to determine the clinical indications for empiric antifungal therapy.</p><p><b>METHODS</b>All 41 cases of catheter-related candidemia from September 2009 to August 2011 at a teaching hospital were included in the present study. To determine the characteristics that were risk factors for developing catheter-related candidemia, we compared all cases of catheter-related candidemia with all 107 cases of catheter-related blood stream infection (CRBSI) caused by non-Candida spp.</p><p><b>RESULTS</b>In comparison with CRBSI due to non-Candida spp., the duration of catheter use was significantly longer in cases of catheter-related candidemia (13.9 ± 9.0 days vs. 23.2 ± 25.2 days). There was also a significant difference in the frequency of pre-antibiotic treatment between catheter-related candidemia and CRBSI due to non-Candida spp. (97.6% [40/41 cases] vs. 44.9% [48/107 cases]). Patients with catheter-related candidemia also had significantly more severe clinical statuses (measured using the Sepsis-related Organ Failure Assessment score) than patients with CRBSI due to non-Candida spp. (7.63 ± 3.65 vs. 5.92 ± 2.81).</p><p><b>CONCLUSION</b>When compared to patients with CRBSI caused by non-Candida spp., patients with catheter-related candidemia had significantly more severe clinical backgrounds, longer duration of catheter use and more frequent prior administration of antibiotic agents.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virulence
/
Candida
/
Case-Control Studies
/
Diagnosis
/
Catheter-Related Infections
/
Candidemia
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
/
Screening study
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Singapore medical journal
Year:
2014
Type:
Article
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