A study of the ultrastructure and gene location of hereditary gingival fibromatosis / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 170-172, 2002.
Article
in English
| WPRIM
| ID: wpr-244809
ABSTRACT
<p><b>OBJECTIVE</b>To ascertain histology changes of hereditary gingival fibromatosis (HGF) and the location of HGF gene.</p><p><b>METHODS</b>A pedigree analyses of HGF; and the ultrastructure of gingival overgrowth tissue was observed with electron microscopy. The overgrowth of the HGF gene was defined with microsatellite markers.</p><p><b>RESULTS</b>The connective tissue of HGF consisted of coarse collagen bundles and several kinds of cells arranged abnormally, such as epithelial cells, smooth muscle cells and so on; the HGF locus had been mapped to chromosome 5q13-q22.</p><p><b>CONCLUSIONS</b>The gingival pathologic changes resemble "hamartoma"; the findings has implications for identification of the underlying genetic basis of HGF.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pedigree
/
Chromosomes, Human, Pair 5
/
Microscopy, Electron
/
Family Health
/
Chromosome Mapping
/
Microsatellite Repeats
/
Genetic Predisposition to Disease
/
Fibromatosis, Gingival
/
Genetics
Type of study:
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Stomatology
Year:
2002
Type:
Article
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