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A study of the ultrastructure and gene location of hereditary gingival fibromatosis / 中华口腔医学杂志
Chinese Journal of Stomatology ; (12): 170-172, 2002.
Article in English | WPRIM | ID: wpr-244809
ABSTRACT
<p><b>OBJECTIVE</b>To ascertain histology changes of hereditary gingival fibromatosis (HGF) and the location of HGF gene.</p><p><b>METHODS</b>A pedigree analyses of HGF; and the ultrastructure of gingival overgrowth tissue was observed with electron microscopy. The overgrowth of the HGF gene was defined with microsatellite markers.</p><p><b>RESULTS</b>The connective tissue of HGF consisted of coarse collagen bundles and several kinds of cells arranged abnormally, such as epithelial cells, smooth muscle cells and so on; the HGF locus had been mapped to chromosome 5q13-q22.</p><p><b>CONCLUSIONS</b>The gingival pathologic changes resemble "hamartoma"; the findings has implications for identification of the underlying genetic basis of HGF.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pedigree / Chromosomes, Human, Pair 5 / Microscopy, Electron / Family Health / Chromosome Mapping / Microsatellite Repeats / Genetic Predisposition to Disease / Fibromatosis, Gingival / Genetics Type of study: Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: Chinese Journal of Stomatology Year: 2002 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pedigree / Chromosomes, Human, Pair 5 / Microscopy, Electron / Family Health / Chromosome Mapping / Microsatellite Repeats / Genetic Predisposition to Disease / Fibromatosis, Gingival / Genetics Type of study: Prognostic study Limits: Child / Female / Humans / Male Language: English Journal: Chinese Journal of Stomatology Year: 2002 Type: Article